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bone cement as a local chemotherapeutic drug delivery

bone cement as a local chemotherapeutic drug delivery

Bone cement as a local chemotherapeutic drug

2020-12-16  The use of bone cements as a chemotherapeutic drug carrier in an attempt to reduce tumor recurrence has been the subject of many studies in the literature. The purpose of this review was to critically examine this body of work.

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Bone cement as a local chemotherapeutic drug

This has led to the introduction and evaluation of poly (methyl methacrylate) and inorganic bone cements as local carriers for chemotherapeutic drugs (usually, antineoplastic drugs (ANPDs)). The present work is a critical review of the literature on the potential use of these cements in orthopedic oncology.

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A PMMA bone cement composite that functions as a

2021-6-13  As an alternative to injectable and biodegradable localized chemotherapeutic delivery systems, poly(methyl methacrylate) (PMMA) bone cement has been utilized as a depot to treat bone tumors [47]–[51]. Due to its prior longstanding use in orthopaedic surgery for fixation of

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A PMMA bone cement composite that functions as a

2021-6-13  A PMMA bone cement composite that functions as a drug-refillable depot for localized, multi-window chemotherapeutic treatment of bone cancer bioRxiv bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

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An injectable calcium phosphate cement for the local ...

Bone metastases are usually treated by surgical removal, fixation and chemotherapeutic treatment. Bone cement is used to fill the resection voids. The aim of this study was to develop a local drug delivery system using a calcium phosphate cement (CPC) as carrier for chemotherapeutic agents.

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Chemistry of glass-ionomer cements: a review -

1998-4-1  Bone cement as a local chemotherapeutic drug delivery carrier in orthopedic oncology: A review

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Calcium phosphate cements as bone drug delivery

2006-6-28  Unlike calcium phosphate ceramics employed as drug delivery systems, where the drugs are usually absorbed on the surface, in CPCs the drugs can be incorporated throughout the whole material volume, by adding them into one of the two cement phases. This fact can facilitate the release of drugs for more prolonged times.

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Dendritic Glycopolymer as Drug Delivery System for ...

Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and

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Dendritic Glycopolymer as Drug Delivery System for ...

2015-5-28  Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions

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Collagen-hydroxyapatite/Cisplatin Drug Delivery Systems ...

2018-2-20  drug delivery system could be a feasible approach for locoregional chemotherapy of bone cancer. Key words: Bone cancer treatment; Cisplatin; Composite; Drug delivery system; Scaffold; Osteoblast; Bone graft; Multifunctional material. Introduction Osteosarcoma is the most common type of primary bone cancer which affects

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An injectable calcium phosphate cement for the local ...

Bone cement is used to fill the resection voids. The aim of this study was to develop a local drug delivery system using a calcium phosphate cement (CPC) as carrier for chemotherapeutic agents. CPC consisted of alpha-tricalcium phosphate, calcium phosphate dibasic and precipitated hydroxyapatite powders and a 2% Na2HPO4 hardening solution.

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Frontiers Development of Natural-Based Bone

2020-7-9  Studies on CPCs used as localized drug delivery systems, loaded with synthetic polymer nanoparticles containing painkillers, antibiotics, and chemotherapeutic drugs (including OS treating drugs) to treat bone cancers demonstrated a reduced risk of local cancer recurrence due to localized and targeted delivery of drugs (Lopez-Heredia et al ...

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Method for the Physical Analysis of Drug-bone

2020-5-28  Delivery of drug locally to bone using bone cement is an attractive option, as it may limit the systemic side effects of chemotherapy while at the same time creating stability in tumor-affected bone. Local drug delivery is also a possible way of treating ischemic tissue in which blood flow is diminished and systemically administered drugs would ...

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PMMA to stabilize bone and deliver antineoplastic

2003-10-1  Bone cement as a local chemotherapeutic drug delivery carrier in orthopedic oncology: A review. Phull SS, Yazdi AR, Ghert M, Towler MR. J Bone Oncol, 26:100345, 16 Dec 2020 Cited by: 0 articles PMID: 33552885 PMCID: PMC7856326. Review Free to read use

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Aseptic loosening Gene Therapy

2004-1-15  The appearance of the periprosthetic membrane at the cement/bone interface shares some histological characteristics ... Bone cement as a local chemotherapeutic drug delivery carrier in

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SOLVENT EFFECTS ON DOXORUBICIN STABILITY IN BONE

2020-9-23  significant sites. PMMA cement is the most widely used local drug delivery system for antibiotics in total joint arthroplasty and the treatment of osteomyelitis. It may also provide sustained release of cancer chemotherapeutic agents for treating metastatic and primary bone tumors while minimizing systemic drug effects.

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Dendritic Glycopolymer as Drug Delivery System for ...

1. Macromol Biosci. 2015 Sep;15(9):1283-95. doi: 10.1002/mabi.201500085. Epub 2015 May 28. Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions.

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Antibiotic-impregnated acrylic bone cement. -

Bone cement as a local chemotherapeutic drug delivery carrier in orthopedic oncology: A review. Phull SS, Yazdi AR, Ghert M, Towler MR. J Bone Oncol, 26:100345, 16 Dec 2020 Cited by: 0 articles PMID: 33552885 PMCID: PMC7856326. Review Free to read use

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Dendritic Glycopolymer as Drug Delivery System for ...

2015-5-28  Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions Christin Striegler Leibniz‐Institut für Polymerforschung Dresden e.V., Hohe Straße 6,

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Dendritic Glycopolymer as Drug Delivery System for ...

Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendriti

get price

An injectable calcium phosphate cement for the local ...

Bone cement is used to fill the resection voids. The aim of this study was to develop a local drug delivery system using a calcium phosphate cement (CPC) as carrier for chemotherapeutic agents. CPC consisted of alpha-tricalcium phosphate, calcium phosphate dibasic and precipitated hydroxyapatite powders and a 2% Na2HPO4 hardening solution.

get price

Frontiers Development of Natural-Based Bone

2020-7-9  Studies on CPCs used as localized drug delivery systems, loaded with synthetic polymer nanoparticles containing painkillers, antibiotics, and chemotherapeutic drugs (including OS treating drugs) to treat bone cancers demonstrated a reduced risk of local cancer recurrence due to localized and targeted delivery of drugs (Lopez-Heredia et al ...

get price

An injectable calcium phosphate cement for the local ...

2011-5-6  Bone metastases are usually treated by surgical removal, fixation and chemotherapeutic treatment. Bone cement is used to fill the resection voids. The aim of this study was to develop a local drug delivery system using a calcium phosphate cement (CPC) as carrier for chemotherapeutic agents.

get price

Calcium phosphate bone cements: a comprehensive

2003-1-1  Bone cement as a local chemotherapeutic drug delivery carrier in orthopedic oncology: A review. Phull SS, Yazdi AR, Ghert M, Towler MR. J Bone Oncol, 26:100345, 16 Dec 2020 Cited by: 0 articles PMID: 33552885 PMCID: PMC7856326. Review Free to read use

get price

Method for the Physical Analysis of Drug-bone

2020-5-28  Delivery of drug locally to bone using bone cement is an attractive option, as it may limit the systemic side effects of chemotherapy while at the same time creating stability in tumor-affected bone. Local drug delivery is also a possible way of treating ischemic tissue in which blood flow is diminished and systemically administered drugs would ...

get price

Aseptic loosening Gene Therapy

2004-1-15  The appearance of the periprosthetic membrane at the cement/bone interface shares some histological characteristics ... Bone cement as a local chemotherapeutic drug delivery carrier in

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Local Delivery System for the Chemotherapeutic Drug ...

2009-4-2  Local Delivery System for the Chemotherapeutic Drug Paclitaxel ... range from total vertebral body replacements to minimally invasive procedures such as percutaneous vertebroplasty where bone cement is injected into the anterior portion of the damaged vertebrae in an effort to provide stabilization. ... The drug delivery device allows the local ...

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PMMA BONE CEMENT: WHAT IS THE ROLE OF LOCAL

2020-5-13  PMMA cement has been combined with an AB agent, which is in the majority of cases the aminoglycosides gentamicin or tobramycin. The first such commercial-ly available ALBC were in-troduced in the 70ies in the market as pharmaceutical products. In order to fur-ther improve the function of PMMA as a local drug delivery system and to adapt

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Bisphosphonate-loaded Bone Cement as a Local

We examined the effects of an alternative intraoperative local delivery of BP on GCTs. Materials and methods: In total, 17 patients with GCTs underwent extended surgical curettage procedures consisting of high-speed burring, traditional adjuvant therapy, and application of BP-loaded polymethylmethacrylate bone cement.

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Dendritic Glycopolymer as Drug Delivery System for ...

Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendriti

get price