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asphalt fume dermal carcinogenicity potential i dermal

asphalt fume dermal carcinogenicity potential i dermal

Asphalt fume dermal carcinogenicity potential: I.

2011-10-1  Studies conducted by the National Institute of Occupational Safety and Health (NIOSH) of fume condensates generated from Types I and III built-up roofing asphalt (BURA) resulted in the development of skin tumors in mouse dermal carcinogenicity studies (Niemeier et al., 1988, Sivak et al., 1997), which have been used extensively to monitor the presence of polycyclic aromatic compounds

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Asphalt fume dermal carcinogenicity potential: I.

Field matched fume condensates from paving and (oxidized) Type III built up roofing asphalts (BURA) were evaluated in mouse dermal carcinogenicity assays. A third sample was generated from the BURA using a NIOSH laboratory generation method. The paving fume condensate produced a single benign tumor and was not carcinogenic under the test conditions. The lab generated fume resulted in a significantly greater tumor response than the field-matched fume (55 versus 13%). Dermal carcinogenicity ...

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Skin carcinogenicity of condensed asphalt roofing

1997-7-1  Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates. Clark CR, Burnett DM, Parker CM, Arp EW, Swanson MS, Minsavage GD, Kriech AJ, Osborn LV, Freeman JJ, Barter RA, Newton PE, Beazley SL, Stewart CW

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Skin carcinogenicity of condensed asphalt roofing

In addition, the neat asphalt fume was tested on Sencar mice to determine if this strain was more susceptible to the carcinogenic effects of the fumes. Condensed neat asphalt fumes produced similar and statistically significant increased tumor yields of papillomas and carcinomas in both strains as compared to respective vehicle controls.

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Review of mechanistic studies relevant to the

Two-year rodent inhalation studies and recent European epidemiology research have shown that asphalt fume alone does not pose a carcinogenic risk to humans. Dermal exposure to asphalt fume condensate have produced skin tumors in mouse skin painting studies but no skin cancer studies in humans have been reported occupationally.

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Asphalt - Registration Dossier - ECHA

In a key carcinogenicity dermal skin painting study (Clark et al., 2011), the carcinogenic potential of fume condensate from a tank paving grade asphalt (TP-D), collected from the head space of an asphalt storage tank, was tested in a mouse skin painting study. Aliquots (37.5 μl) of the tank paving asphalt fume condensate dissolved in mineral oil were painted daily on the shaved back of 80 male C3H/HeNCrL

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HEALTH EFFECTS OF OCCUPATIONAL EXPOSURE TO

2017-3-27  airborne and dermal exposures to asphalt fumes and aerosols and the potential for chronic health effects, including cancer, warrant continued diligence in the control of exposures. NIOSH and its labor and industry partners are making great strides in reducing worker exposures to

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eLCOSH : Asphalt in Construction: An Interdisciplinary ...

"Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates." Regul Toxicol Pharmacol 61(1): 9‐16. Asphalt (bitumen) fume condensates collected from the headspace above paving and Type III built up roofing asphalt (BURA) tanks were evaluated in two‐year dermal carcinogenicity assays in male C3H/HeNCrl mice.

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Updated Eurobitume Technical Guidance on Maximum

2016-3-2  3 Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates. Clark CR, Burnett DM, Parker CM, Arp EW, Swanson MS, Minsavage GD, Kriech AJ, Osborn LV, Freeman JJ, Barter RA, Newton PE, Beazley SL, Stewart CW. Regul Toxicol Pharmacol. 2011 Oct;61(1):9-16. Epub 2011 Apr 18.

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The Health Effects of Occupational Exposure to Asphalt

2021-3-4  heprimary source of the renewed scientific interest in the possible carcinogenicity of asphalt fumes arises from two NIOSH skin-painting bioassays of experimental mice.(29,30) Thesestudies involved roofing asphalt fume condensates that were specially prepared according to a novel laboratory procedure. In the first study, laboratory fume condensates

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HEALTH EFFECTS OF OCCUPATIONAL EXPOSURE TO

2017-3-27  airborne and dermal exposures to asphalt fumes and aerosols and the potential for chronic health effects, including cancer, warrant continued diligence in the control of exposures. NIOSH and its labor and industry partners are making great strides in reducing worker exposures to paving and roofing asphalt

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The Health Effects of Occupational Exposure to Asphalt

2021-3-4  has acknowledged, the source of the dermal carcinogenicity seen in the NIOSH mouse studies continues to elude us.(30) Nevertheless, the NIOSH laboratory fume mouse studies have raised questions about whether there is a possible cancer risk to workers exposed to the asphalt fumes created in real-world manufacturing and application operations.

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eLCOSH : Asphalt in Construction: An Interdisciplinary ...

"Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates." Regul Toxicol Pharmacol 61(1): 9‐16. Asphalt (bitumen) fume condensates collected from the headspace above paving and Type III built up roofing asphalt (BURA) tanks were evaluated in two‐year dermal carcinogenicity ...

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Updated Eurobitume Technical Guidance on Maximum

2016-3-2  3 Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates. Clark CR, Burnett DM, Parker CM, Arp EW, Swanson MS, Minsavage GD, Kriech AJ, Osborn LV, Freeman JJ, Barter RA, Newton PE, Beazley SL, Stewart CW. Regul Toxicol Pharmacol. 2011 Oct;61(1):9-16. Epub 2011 Apr 18.

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Health Effects of Occupational Exposure to Asphalt

2014-6-6  Observations of acute irritation in workers from airborne and dermal exposures to asphalt fumes and aerosols and the potential for chronic health effects, including cancer, warrant continued diligence in the control of exposures. Health Effects of Occupational Exposure to Asphalt pdf

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SOUTHEAST ASPHALT USER PRODUCER SCOPE OF

2014-4-11  1. Evidence of dermal uptake limited to 2, 3 and 4 ring PAH’s‐generally considered to be non‐carcinogenic 2. Diesel fuel used for clean up appears to be a significant contributor to dermal exposure either by itself or due to solvent effect on fume condensate or whole asphalt 27 Hwy 33 Hot Mix Mat H o t M i x S c r e

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Quantitative cancer risk assessment for occupational ...

2015-10-29  Dermal carcinogenicity bioassays using mice report increased tumor incidence with single high doses. In order to quantify potential cancer risks, ... We apply similar approaches to limited data on asphalt-fume inhalation and respiratory cancers in rats. We also develop a method for adjusting potency estimates for asphalts that vary in ...

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bitumens and bitumen derivatives

2013-10-22  Carcinogenicity 8 4.3.1.1. Dermal Carcinogenicity Studies 9 4.3.1.2. Subcutaneous and Intramuscular Studies 11 ... asphalt etc., it is essential to be clear about terminology. In this dossier, ... Bitumen or Bitumen Bitumen Condensed Bitumen Condensed Condensed Condensed Pitch Fume Condensed Fume Fume Fume Fume Fume (Temperature °C) (160) (250 ...

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Asphalt fumes: The current situation and a peek at the ...

2004-10-1  Asphalt fumes: The current situation and a peek at the future. The controversy about possible cancer-causing effects of asphalt fumes has been with the roofing industry for quite some time. Since the 1980s, NRCA and other roofing

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Review of Skin Permeation Hazard of Bitumen Fumes

2018-6-19  The potential for health hazards arising from dermal exposure and possible uptake of bitumen fume or components is unclear. In 2001 the German MAK committee has assigned a “H-notation” to bitumen fumes. However, the assignment of a skin notation to bitumen fumes is under debate. The American Conference of Governmental Industrial Hygienists

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SOUTHEAST ASPHALT USER PRODUCER SCOPE OF

2014-4-11  1. Evidence of dermal uptake limited to 2, 3 and 4 ring PAH’s‐generally considered to be non‐carcinogenic 2. Diesel fuel used for clean up appears to be a significant contributor to dermal exposure either by itself or due to solvent effect on fume condensate or whole asphalt 27 Hwy 33 Hot Mix Mat H o t M i x S c r e

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Inhalation and Dermal Exposure among Asphalt

Because asphalt workers are occupationally exposed to PAHs via inhalation and dermal absorption, the carcinogenic potential of asphalt has been under investigation since the 1960s. In fact, numerous epidemiological studies have described an excess risk of cancer (lung, stomach, bladder, leukemia, and non-melanoma skin cancer) among asphalt ...

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Paving Asphalt Products Exhibit a Lack The Author(s) 2011 ...

2019-11-3  weekly for 2 years did not produce evidence of dermal carci-nogenesis (0%-2% tumor-bearing animals).5 A fifth sample, a paving asphalt, exhibited a weak potential for carcinogenicity (4%tumor-bearinganimals).Similartotheresultswithasphalt, application of vacuum residuum diluted in toluene for 130 weeks (twice weekly) produced tumors in 5 of 50 mice

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bitumens and bitumen derivatives

2013-10-22  Carcinogenicity 8 4.3.1.1. Dermal Carcinogenicity Studies 9 4.3.1.2. Subcutaneous and Intramuscular Studies 11 ... asphalt etc., it is essential to be clear about terminology. In this dossier, ... Bitumen or Bitumen Bitumen Condensed Bitumen Condensed Condensed Condensed Pitch Fume Condensed Fume Fume Fume Fume Fume (Temperature °C) (160) (250 ...

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Recent trends of the emission characteristics from the ...

2010-5-19  Of specific concern is the potential carcinogenicity of bitumen fume inhalation. ... reported low PAH content in dermal wipe samples of hot mix asphalt plant workers and members of road-paving crews. Skin wipe samples were analyzed for 17 PAH, though only six PAH were detectable in all of these analyses. ... pyrene levels in asphalt fume ...

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Asphalt fumes: The current situation and a peek at the ...

2004-10-1  Asphalt fumes: The current situation and a peek at the future. The controversy about possible cancer-causing effects of asphalt fumes has been with the roofing industry for quite some time. Since the 1980s, NRCA and other roofing

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safety

2018-3-26  he controversy surrounding the potential cancer-causing effects of asphalt fume exposures experi - enced during hot roofing work has existed for a lmost 35 years. But the debate recently took a posi - tive turn with the publication of a quantitative risk assessment (QRA) of asphalt roofing fumes. The

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Review of Skin Permeation Hazard of Bitumen Fumes

2018-6-19  The potential for health hazards arising from dermal exposure and possible uptake of bitumen fume or components is unclear. In 2001 the German MAK committee has assigned a “H-notation” to bitumen fumes. However, the assignment of a skin notation to bitumen fumes is under debate. The American Conference of Governmental Industrial Hygienists

get price

Comparing Urinary Biomarkers of Airborne and

The authors concluded that the effect of dermal exposure to asphalt emissions on OH-Pyr levels was ∼eight times that of inhalation exposure and that the effect of inhalation exposure was more apparent immediately after the work shift, while the effect of dermal exposure was more apparent during the period of 8–16 h after the work shift ...

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MSDS New QUIK Stick - Caboose CMS

2017-5-1  Potential Health Effects Inhalation: Inhalation of vapors, fumes or mists of the products in abnormal or emergency circumstances ... or TLV for asphalt fume is exceeded, use any half-facepiece, air purifying respirator ... operations may result in worker exposures to asphalt fumes or emissions via inhalation or dermal absorption. Although there ...

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